HGK Rabbit Polyclonal Antibody

Name: HGK Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES2511
Price: 248.0 USD
Availability: InStock

$248.00 USD

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HGK Rabbit Polyclonal Antibody

Product name:	HGK rabbit pAb
Alternative Names:	MAP4K4; HGK; KIAA0687; NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase
Applications:	WB;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human MEKKK 4. AA range:406-455
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	142kD
GeneID（Human）:	9448
Human Swiss-Prot No:	O95819
Cellular localization:	Cytoplasm .
Background:	mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Species Reactivity:	Human;Mouse

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