GIT2 Rabbit Polyclonal Antibody

Name: GIT2 Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES2427
Price: 248.0 USD
Availability: InStock

$248.00 USD

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GIT2 Rabbit Polyclonal Antibody

Overview

Product name:	GIT2 rabbit pAb
Alternative Names:	GIT2; KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Applications:	WB;IHC;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human GIT2. AA range:361-410
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	84kD
GeneID（Human）:	9815
Human Swiss-Prot No:	Q14161
Cellular localization:	nucleoplasm,focal adhesion,
Background:	This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
Species Reactivity:	Human;Mouse;Rat

Western Blot analysis of various cells using GIT2 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western Blot analysis of HepG2 cells using GIT2 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Immunohistochemical analysis of paraffin-embedded Human cervix cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absor
Western blot analysis of lysates from HepG2 cells, using GIT2 Antibody. The lane on the right is blocked with the synthesized peptide.

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GIT2 Rabbit Polyclonal Antibody

GIT2 Rabbit Polyclonal Antibody

Overview