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ELK Biotechnology

ES2314

Factor VIII Rabbit Polyclonal Antibody

Factor VIII Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Factor VIII Rabbit Polyclonal Antibody

Overview

Product name: Factor VIII rabbit pAb
Alternative Names: F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Factor VIII. AA range:2161-2210
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 300kD
GeneID（Human）: 2157
Human Swiss-Prot No: P00451
Cellular localization: Secreted, extracellular space.
Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008],
Species Reactivity: Human;Mouse
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