Dyrk1A Rabbit Polyclonal Antibody

Name: Dyrk1A Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES2210
Price: 248.0 USD
Availability: InStock

$248.00 USD

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Dyrk1A Rabbit Polyclonal Antibody

Overview

Product name:	Dyrk1A rabbit pAb
Alternative Names:	DYRK1A; DYRK; MNB; MNBH; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB
Applications:	WB;IHC;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human DYR1A. AA range:21-70
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	90kD
GeneID（Human）:	1859
Human Swiss-Prot No:	Q13627
Cellular localization:	Nucleus . Nucleus speckle .
Background:	This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' co
Species Reactivity:	Human;Mouse;Rat

Western Blot analysis of various cells using Dyrk1A Polyclonal Antibody diluted at 1:500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western Blot analysis of HepG2 cells using Dyrk1A Polyclonal Antibody diluted at 1:500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Immunofluorescence analysis of HepG2 cells, using DYR1A Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HepG2 cells, using DYR1A Antibody. The lane on the right is blocked with the synthesized peptide.

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Dyrk1A Rabbit Polyclonal Antibody

Dyrk1A Rabbit Polyclonal Antibody

Overview