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ELK Biotechnology

ES2079

Cyclin A1 Rabbit Polyclonal Antibody

Cyclin A1 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Cyclin A1 Rabbit Polyclonal Antibody

Overview

Product name: Cyclin A1 rabbit pAb
Alternative Names: CCNA1; Cyclin-A1
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Cyclin A1. AA range:411-460
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 52kD
GeneID（Human）: 8900
Human Swiss-Prot No: P78396
Cellular localization: Nucleus .
Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multi
Species Reactivity: Human;Mouse;Rat
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