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ELK Biotechnology

ES2023

COL4A1 Rabbit Polyclonal Antibody

COL4A1 Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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COL4A1 Rabbit Polyclonal Antibody

Overview

Product name: COL4A1 rabbit pAb
Alternative Names: COL4A1; Collagen alpha-1(IV) chain
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen IV. AA range:11-60
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 160kD
GeneID（Human）: 1282
Human Swiss-Prot No: P02462
Cellular localization: Secreted, extracellular space, extracellular matrix, basement membrane .
Background: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Species Reactivity: Human;Mouse
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