CLK2 Rabbit Polyclonal Antibody

Name: CLK2 Rabbit Polyclonal Antibody
Brand: ELK Biotechnology
SKU: ES2002
Price: 248.0 USD
Availability: InStock

$248.00 USD

Sale Sold out

Shipping calculated at checkout.

Size 100ul

Product variants

Quantity

CLK2 Rabbit Polyclonal Antibody

Overview

Product name:	CLK2 rabbit pAb
Alternative Names:	CLK2; Dual specificity protein kinase CLK2; CDC-like kinase 2
Applications:	WB;IHC;IF;ELISA
Recommended Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human CLK2. AA range:1-50
Storage:	Rabbit
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	60kD
GeneID（Human）:	1196
Human Swiss-Prot No:	P49760
Cellular localization:	Nucleus .; [Isoform 1]: Nucleus . Nucleus speckle . Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. .; [Isoform 2]: Nucleus speckle . Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. .
Background:	CDC like kinase 2(CLK2) Homo sapiens This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
Species Reactivity:	Human;Mouse;Rat

Western Blot analysis of various cells using CLK2 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Western Blot analysis of A549 cells using CLK2 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by i
Western blot analysis of lysates from COLO205 and A549 cells, using CLK2 Antibody. The lane on the right is blocked with the synthesized peptide.

View full details

Country/region

CLK2 Rabbit Polyclonal Antibody

CLK2 Rabbit Polyclonal Antibody

Overview