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ELK Biotechnology

ES1851

Caspase-10 B/C Rabbit Polyclonal Antibody

Caspase-10 B/C Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Caspase-10 B/C Rabbit Polyclonal Antibody

Overview

Product name: Caspase-10 B/D rabbit pAb
Alternative Names: ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 10. AA range:430-479
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: pro: 60kD, actived: 33kD 12kD
GeneID（Human）: 843
Human Swiss-Prot No: Q92851-2/4
Cellular localization: cytosol,CD95 death-inducing signaling complex,ripoptosome,
Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],
Species Reactivity: Human;Rat;Mouse;
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