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ELK Biotechnology
SKU:ES1527
PERK (phospho Thr981) Rabbit Polyclonal Antibody
PERK (phospho Thr981) Rabbit Polyclonal Antibody
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PERK (phospho Thr981) Rabbit Polyclonal Antibody
Overview
| Product name: | PERK (phospho Thr981) rabbit pAb |
| Alternative Names: | EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK |
| Applications: | IF;WB;IHC;ELISA |
| Recommended Dilutions: | IF: 1:50-200 WB 1:500-2000 ,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human PEK/PERK around the phosphorylation site of Thr981. AA range:947-996 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 130kD |
| GeneID（Human）: | 9451 |
| Human Swiss-Prot No: | Q9NZJ5 |
| Cellular localization: | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Background: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015], |
| Species Reactivity: | Human;Mouse;Rat |
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