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ELK Biotechnology

ES1469

Caspase-9 (phospho Thr125) Rabbit Polyclonal Antibody

Caspase-9 (phospho Thr125) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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Caspase-9 (phospho Thr125) Rabbit Polyclonal Antibody

Overview

Product name: Caspase-9 (phospho Thr125) rabbit pAb
Alternative Names: CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Caspase 9 around the phosphorylation site of Thr125. AA range:91-140
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 46kD
GeneID（Human）: 842
Human Swiss-Prot No: P55211
Cellular localization: nucleus,mitochondrion,cytosol,apoptosome,
Background: CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
Species Reactivity: Human;Mouse;Rat
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