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ELK Biotechnology

ES1370

NFκB-p65 (phospho Ser529) Rabbit Polyclonal Antibody

NFκB-p65 (phospho Ser529) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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NFκB-p65 (phospho Ser529) Rabbit Polyclonal Antibody

Overview

Product name: NFκB-p65 (phospho Ser529) rabbit pAb
Alternative Names: RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Applications: IF;WB;IHC;ELISA
Recommended Dilutions: IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human NFκB-p65 (phospho Ser529)
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 60kD
GeneID（Human）: 5970
Human Swiss-Prot No: Q04206
Cellular localization: Nucleus . Cytoplasm . Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333). Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135). Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752). Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622). .
Background: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Species Reactivity: Human;Mouse;Rat;Monkey
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