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ELK Biotechnology
SKU:ES1290
c-Myc (phospho Thr58) Rabbit Polyclonal Antibody
c-Myc (phospho Thr58) Rabbit Polyclonal Antibody
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c-Myc (phospho Thr58) Rabbit Polyclonal Antibody
Overview
| Product name: | c-Myc (phospho Thr58) rabbit pAb |
| Alternative Names: | MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Applications: | WB;IHC;IF;IP;ELISA |
| Recommended Dilutions: | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr58. AA range:25-74 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 50,(also ~60KD in some samples) |
| GeneID（Human）: | 4609 |
| Human Swiss-Prot No: | P01106 |
| Cellular localization: | Nucleus, nucleoplasm . Nucleus, nucleolus . |
| Background: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Mouse;Rat |
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