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ELK Biotechnology

ES1259

AMPKβ1 (phospho Ser182) Rabbit Polyclonal Antibody

AMPKβ1 (phospho Ser182) Rabbit Polyclonal Antibody

$248.00 USD
$248.00 USD
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AMPKβ1 (phospho Ser182) Rabbit Polyclonal Antibody

Overview

Product name: AMPKβ1 (phospho Ser182) rabbit pAb
Alternative Names: PRKAB1; AMPK; 5'-AMP-activated protein kinase subunit beta-1; AMPK subunit beta-1; AMPKb
Applications: WB;IHC;IF;ELISA
Recommended Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK beta1 around the phosphorylation site of Ser181. AA range:147-196
Storage: Rabbit
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 38kD
GeneID（Human）: 5564
Human Swiss-Prot No: Q9Y478
Cellular localization: nucleus,nucleoplasm,cytosol,nucleotide-activated protein kinase complex,
Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided
Species Reactivity: Human;Mouse;Rat
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