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ELK Biotechnology
SKU:ES1001
Cleaved-Caspase-3 p12 (D175) Rabbit Polyclonal Antibody
Cleaved-Caspase-3 p12 (D175) Rabbit Polyclonal Antibody
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Cleaved-Caspase-3 p12 (D175) Rabbit Polyclonal Antibody
Overview
| Product name: | Cleaved-Caspase-3 p12 (D175) rabbit pAb |
| Alternative Names: | CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 |
| Applications: | WB;IF;IHC;ELISA |
| Recommended Dilutions: | WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Caspase 3. AA range:157-206 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 12 35kD |
| GeneID（Human）: | 836 |
| Human Swiss-Prot No: | P42574 |
| Cellular localization: | Cytoplasm. |
| Background: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008], |
| Species Reactivity: | Human;Rat;Mouse; |
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