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ELK Biotechnology

EM1320

phospho-MLKL (S358) (6B4) Mouse Monoclonal Antibody

phospho-MLKL (S358) (6B4) Mouse Monoclonal Antibody

$248.00 USD
$248.00 USD
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phospho-MLKL (S358) (6B4) Mouse Monoclonal Antibody

Overview

Product name: phospho-MLKL (S358) (6B4) Mouse mAb
Reactivity: Human
Alternative Names: Mixed lineage kinase domain like protein, FLJ34389
Source: Mouse
Applications: IHC
Species: Human
Recommended dilutions:  IHC 1:100-200
Immunogen: Synthetic Peptide
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/ml
Observed band: 54kDa
GeneID（Human）: 197259
Human Swiss-Prot No: Q8NB16
Cellular localization: Cell membrane, Cytoplasm, Membrane
Background: Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.
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