Glial Fibrillary Acidic Protein ;Intermediate Filament Protein
Source:
Mouse
Applications:
WB, IHC
Species:
Human
Recommended dilutions:
WB 1:2,000-5,000 IHC 1:200-500
Immunogen:
Synthetic Peptide
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality:
Monoclonal
Isotype:
IgG1
Concentration:
1mg/ml
Observed band:
45kDa
GeneID（Human）:
2670
Human Swiss-Prot No:
P14136
Cellular localization:
Cytoplasm. Associated with intermediate filaments
Background:
GFAP is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.
