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ELK Biotechnology
SKU:EM1056
CK16 Mouse Monoclonal Antibody
CK16 Mouse Monoclonal Antibody
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$248.00 USD
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CK16 Mouse Monoclonal Antibody
Overview
| Product name: | CK16 Mouse mAb |
| Reactivity: | Human, Rat, Mouse |
| Alternative Names: | Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
| Source: | Mouse |
| Applications: | IHC |
| Species: | Human, Rat, Mouse |
| Species: | Human |
| Recommended dilutions: | IHC 1:200 |
| Immunogen: | Synthetic Peptide |
| Storage: | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Concentration: | 1mg/ml |
| Observed band: | 51kDa |
| GeneID（Human）: | 3868 |
| Human Swiss-Prot No: | P08779 |
| Cellular localization: | Intermediate filament |
| Background: | Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. |
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