Mucin 5AC

This antibody reacts with a 1000 kDa protein and recognizesthe peptide core of gastric mucin M1. Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric mucin M1 antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either reexpression of the peptide core of gastric mucin in the adult colon or changes in the glycosylation pattern of mucin, which expose the hidden M1 antigen.