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Dima Biotech

PME100659

Human NEFL Protein, hFc Tag

Human NEFL Protein, hFc Tag

$478.00 USD
$478.00 USD
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Size
Target
Uniprot ID
PRODUCT DATA
TARGET

SYNONYMS

CMT1F;CMT2E;CMTDIG;NF-L;NF68;NFL;PPP1R110
DESCRIPTION

Recombinant Human NEFL with C-terminal human Fc tag
DELIVERY

In Stock
UNIPROT ID

P07196
EXPRESSION HOST

HEK293
TAG

C-Human Fc Tag
MOLECULAR CHARACTERIZATION

NEFL(Ser2-Asp543) hFc(Glu99-Ala330)
MOLECULAR WEIGHT

The protein has a predicted molecular mass of 87.5 kDa after removal of the signal peptide. The apparent molecular mass of NEFL-hFc is approximately 35-55 kDa due to glycosylation.
PURITY

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
FORMULATION & RECONSTITUTION

Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
USAGE

Research use only
IMAGES

sp-PME100659 NEFL hFc PAGE 300

Figure 1. Human NEFL Protein, hFc Tag on SDS-PAGE under reducing condition.

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