| TARGET | |
|---|---|
| SYNONYMS |
Brain-Derived Neurotrophic Factor;BDNF;Abrineurin |
| DESCRIPTION |
Recombinant Human Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding His129-Arg247 is expressed. |
| DELIVERY |
In Stock |
| UNIPROT ID |
P23560 |
| EXPRESSION HOST |
E.coli |
| TAG | |
| MOLECULAR CHARACTERIZATION |
Not available |
| MOLECULAR WEIGHT |
13 KDa |
| PURITY |
Greater than 95% as determined by reducing SDS-PAGE. |
| FORMULATION & RECONSTITUTION |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. |
| USAGE |
Research use only |
Dima Biotech
SKU:PME30010
Human/Murine/Rat BDNF Protein
Human/Murine/Rat BDNF Protein
Regular price
$503.00 USD
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PRODUCT DATA
IMAGES
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
Figure 2. Immobilized Human TrkB-His at 2ug/ml (100 μl/well) can bind Human BDNF*: Biotinylated by NHS-biotin prior to testing. The ED50 of Human BDNF* is 47.58 ng/ml.
