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Dima Biotech

PME30038

Human proHB-EGF (C-6His) Protein

Human proHB-EGF (C-6His) Protein

$131.00 USD
$131.00 USD
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Size
Target
Uniprot ID
PRODUCT DATA
TARGET

SYNONYMS

Diphtheria toxin receptor;DTR;EGFL;heparin-binding EGF-like growth factor;DTS;DTSF;heparin-binding epidermal growth factor;proheparin-binding EGF-like growth factor;HB-EGF;pro HB-EGF
DESCRIPTION

Recombinant Human Heparin Binding EGF like Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu20-Leu148 is expressed with a 6His tag at the C-terminus.
DELIVERY

In Stock
UNIPROT ID

Q99075
EXPRESSION HOST

HEK293
TAG

C-6×His Tag
MOLECULAR CHARACTERIZATION

Not available
MOLECULAR WEIGHT

15.1 KDa
PURITY

Greater than 95% as determined by reducing SDS-PAGE.
FORMULATION & RECONSTITUTION

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF-like domain, and a heparin-binding motif. Mature HB-EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB-EGF shows 76% and 73% aa sequence identity with rat and mouse HB-EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HB-EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non-mitogenic actions, while EGFR binding induces both mitogenic and non-mitogenic activity.
USAGE

Research use only
IMAGES

sp-PME30038 CS13 Q99075 SDS PAGE 0

Figure 1. Greater than 95% as determined by reducing SDS-PAGE.

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