| TARGET | |
|---|---|
| SYNONYMS |
Ciliary Neurotrophic Factor;CNTF |
| DESCRIPTION |
Recombinant Human Ciliary Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala2-Met200 is expressed. |
| DELIVERY |
In Stock |
| UNIPROT ID |
P26441 |
| EXPRESSION HOST |
E.coli |
| TAG | |
| MOLECULAR CHARACTERIZATION |
Not available |
| MOLECULAR WEIGHT |
22.93 KDa |
| PURITY |
Greater than 95% as determined by reducing SDS-PAGE. |
| FORMULATION & RECONSTITUTION |
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown. |
| USAGE |
Research use only |
Dima Biotech
SKU:PME30084
Human CNTF Protein
Human CNTF Protein
Regular price
$400.00 USD
Regular price
Sale price
$400.00 USD
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PRODUCT DATA
IMAGES
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
