| TARGET | |
|---|---|
| SYNONYMS |
ACVRLK7;ALK7 |
| DESCRIPTION |
Recombinant Human ACVR1C Protein with C-terminal human Fc tag |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q8NER5 |
| EXPRESSION HOST |
HEK293 |
| TAG |
C-Human Fc Tag |
| MOLECULAR CHARACTERIZATION |
ACVR1C(Leu22-Glu113) hFc(Glu99-Ala330) |
| MOLECULAR WEIGHT |
The protein has a predicted molecular mass of 36.0 kDa after removal of the signal peptide. The apparent molecular mass of ACVR1C-hFc is approximately 35-70 kDa due to glycosylation. |
| PURITY |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
| USAGE |
Research use only |
Dima Biotech
SKU:PME101233
Human ACVR1C Protein, hFc Tag
Human ACVR1C Protein, hFc Tag
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$367.00 USD
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PRODUCT DATA
IMAGES
Figure 1.Human ACVR1C Protein, hFc Tag on SDS-PAGE under reducing condition.
