| TARGET | |
|---|---|
| SYNONYMS |
EP4; EP4R |
| DESCRIPTION |
Human PTGER4 full length protein-synthetic nanodisc |
| DELIVERY |
In Stock |
| UNIPROT ID |
P35408 |
| EXPRESSION HOST |
HEK293 |
| PROTEIN FAMILIES |
Druggable Genome, GPCR, Transmembrane |
| PROTEIN PATHWAYS |
Neuroactive ligand-receptor interaction |
| MOLECULAR WEIGHT |
The human full length PTGER4 protein has a MW of 53.1 kDa |
| FORMULATION & RECONSTITUTION |
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
The protein is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. |
| USAGE |
Research use only |
Dima Biotech
SKU:FLP100097
Human PTGER4 full length protein-synthetic nanodisc
Human PTGER4 full length protein-synthetic nanodisc
Regular price
$900.00 USD
Regular price
Sale price
$900.00 USD
Unit price
per
Shipping calculated at checkout.
Couldn't load pickup availability
PRODUCT DATA
IMAGES
Figure1. Elisa plates were pre-coated with Flag Tag PTGER4-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with PTGER4-Nanodisc is 3.882ng/ml.
Figure2. Human PTGER4-Nanodisc, Flag Tag on SDS-PAGE
