| TARGET | |
|---|---|
| SYNONYMS |
CALCRL; CRLR; LMPHM8 |
| DESCRIPTION |
Human CGRPR-RAMP1 full length protein membrane nanoparticles (MNPs) |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q16602 |
| EXPRESSION HOST |
HEK293 |
| PROTEIN FAMILIES |
Druggable Genome, GPCR, Transmembrane |
| PROTEIN PATHWAYS |
Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction |
| MOLECULAR WEIGHT |
The human full length CGRPR protein has a MW of 53.0 kDa |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity. |
| USAGE |
Research use only |
Dima Biotech
SKU:FLP200145
Human CGRPR-RAMP1 full length protein-MNP
Human CGRPR-RAMP1 full length protein-MNP
Regular price
$1,200.00 USD
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$1,200.00 USD
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PRODUCT DATA
IMAGES
Figure1. Elisa plates were pre-coated with 0.5μg/per well purified human CGRPR-RAMP1 full length membrane nanoparticles. Serial diluted anti-CGRPR monoclonal antibody (BME100166) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CGRPR monoclonal antibody binding with CGRPR-RAMP1 full length membrane nanoparticles is 122.8ng/ml.
