NKp46 polyclonal antibody

NKp46 (lymphocyte antigen 94, LY94) is a natural cytotoxicity receptor that belongs to the immunoglobulin superfamily and is expressed by all resting or activated NK cells, but not on T cells or B cells. The NKp46 cDNA encodes a 304 amino acid type I transmembrane protein with an extracellular region preceded by a 21 residue signal peptide and two cysteine-bridged C2-type Ig-like domains. A stem connects the extracellular domain to a 19 amino acid, arginine containing-transmembrane domain. NKp46 is involved in natural cytotoxicity and is involved in the recognition and lysis of both human and murine tumor cells.