SPDEF polyclonal antibody

Prostate epithelium-specific Ets transcription factor (PDEF), also designated prostate Ets or SAM pointed domain containing Ets transcription factor, is a 335 amino acid nuclear protein. PDEF belongs to the Ets family of proteins. This protein, which localizes to prostate epithelial cells, functions as an Ets transcription factor. It upregulates the activity of the p62 promotor but this activity can be downregulated by PSI. It is also involved in the activation of prostate-specific antigen (PSA) by acting as an androgen-independent transactivator.