MGLL polyclonal antibody

Monoglyceride Lipase (MGL), also known as Lysophospholipase-like or Lysophospholipase homolog, is a ubiquitously expressed protein that functions in the endocannabinoid system. It is required for the the degradation of endocannabinoids and the complete hydrolysis of monoglycerides. In addition, Monoglyceride Lipase functions together with HSL (hormone-sensitive lipase) to hydrolyze intracellular triglyceride to glycerol and fatty acids. Monoglyceride Lipase is a presynaptic, cytosolic enzyme that functions as a serine hydrolase and specifically hydrolyzes 2- and 1(3)-ester bonds of monoglycerides. In particular, Monoglyceride Lipase is responsible for the inactivation and degradation of 2-arachidonoylglycerol (2-AG). 2-AG is a monoglyceride produced by neurons that activates cannabinoid receptors and possibly modulates neurotransmitter release and synaptic plasticity.