MAT1A polyclonal antibody

Methionine adenosyltransferase (MAT) catalyzes the formation of S-adenosyltransferase (AdoMet) for methionine catabolism in the liver. Two different genes, MAT1A and MAT2A, encode a liver specific and non-liver specific form of MAT, designated MAT Iα and MAT IIα, respectively. Inactivation of the liver specific gene product, designated MAT I/III, associates with liver diseases such as cirrhosis. MAT Iα expression also correlates with a differentiated phenotype, whereas liver cells expressing MAT IIα present a dedifferentiated phenotype and lowered AdoMet synthesis. Likewise, NF-kB and TNFα cause a switch from MAT Iα to MAT IIα expression in human hepatocellular carcinoma (HCC), which facilitates cancer cell growth.