KIF2B polyclonal antibody

The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF2B (kinesin family member 2B) is a 673 amino acid cytoplasmic protein that localizes to the kinetochore. Highly expressed in lung and ovary with moderate expression in heart, kidney, placenta skeletal muscle and spleen, KIF2B has microtubule depolymerization activity and is associated with peripheral translocation of lysosomes. Overexpression of KIF2B in cells result in abnormally large lysosome size and unusual positioning, which is some distance from their usual perinuclear location. KIF2B activity is critical for spindle assembly and chromosome movement.