PRAME polyclonal antibody

Several tumor-associated antigen families, such as MAGE, GAGE, PRAME and BAGE, are of interest in tumor immunology because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells. The MAGE, BAGE and GAGE genes code for distinct antigens that are recognized by autologous cytolytic T lymphocytes. Many of these antigens represent suitable targets for tumor immunotherapy because their expression in human melanoma cells is common and highly specific. PRAMEL (preferentially expressed antigen in melanoma-like), also known as leucine-rich repeat-containing protein PRAME-like, is a 520 amino acid protein that belongs to the PRAME family.