TKT polyclonal antibody

Transketolase (TK or TKT), a member of the Transketolase family, is a multifunctional protein that plays a role in diabetes, cancer, Alzheimer’s disease and Wernicke-Korsakoff’s syndrome, a latent genetic neurological disorder. Transketolase is also important for the prevention of hyperglycemia-induced vascular damage. Transketolase is a crucial protein in the pentose phosphate pathway (PPP), where it catalyzes several reactions. In combination with Transaldolase, Transketolase functions as a link between glycolysis and the non-oxidative part of the PPP, allowing the cell to adapt to varying metabolic conditions in response to environmental changes. Transketolase activity is detected in small intestine epithelia, liver parenchyma, tongue, cornea and trachea. It is also expressed in the proximal tubules of kidney and in ganglion cells in medulla of the adrenal gland.