RPL6 polyclonal antibody

Mammalian ribosomal proteins are encoded by multigene families that consist of processed pseudogenes and one functional intron-containing gene within their coding regions. Ribosomal Protein L6, also known as RPL6, TAXREB107 or TXREB1, is a 288 amino acid component of the large ribosomal 60S subunit. Localized to the cytoplasm, Ribosomal Protein L6 binds specifically to domain C of the tax-responsive element (FOXN2) of human T-cell leukemia virus type 1, thereby regulating tax-mediated transcriptional activation. Ribosomal Protein L6 is upregulated in multi-drug resistant (MDR) gastric cancer cells and is implicated in Noonan syndrome, a congenital genetic condition characterized by impaired blood clotting, short stature and indentation of the chest. Two isoforms exist due to alternative splicing events.