OPRL1 polyclonal antibody

Endogenous opioid peptides and opiates like morphine mediate their cellular effects through membrane bound receptors. Three different types of opioid receptors have been identified, mu-type, delta-type and kappa-type. A fourth opioid receptor, KOR-3 (kappa-type opioid receptor, also designated ORL1- Opioid Receptor Like 1), has been identified. Though closely related genetically to the other opioid receptors, KOR-3 has a distinct pharmacological profile. Nociceptin, the neuropeptide which activates KOR-3, is structurally similar to the kappa-opioid peptide dynorphin A, but quite different in its mode of interaction with its receptor. KOR-3 is widely expressed in the nervous system, and is likely to modulate a broad range of physiological and behavioral functions.