TNFSF13B polyclonal antibody

TNF cytokine family member TALL-1 (also designated BAFF, THANK and BLyS), is a type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. TALL-1 is expressed abun-dantly in peripheral blood leukocytes, monocytes and macrophages. TALL-1 is critically involved in the regulation of infections, inflammation, autoimmune diseases and tissue homeostasis. TALL-1 is a potent B cell stimulatory factor which is functionally involved in B cell proliferation and may be a primary mediator in B cell-associated autoimmune diseases. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.