EPC1 polyclonal antibody

Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.