ENPP2 polyclonal antibody

Autotaxin (ATX), also designated ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2), is a membrane-bound glycoprotein that cleaves diester bonds for a broad range of substrates. Originally isolated from the human melanoma cell line (A2058), Autotaxin is predominantly expressed in brain, placenta, ovary and small intestine. Autotaxin has significant homology to the cell membrane differentiation antigen PC-1, and is a stimulator of tumor cell motility. It also functions as a catalyst by hydrollytically removing 5’-nucleotides from the 3’-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.