THP polyclonal antibody

Tamm-Horsfall glycoprotein (also referred to as uromodulin or THP) is the most abundant protein found in normal urine. THP is expressed on the luminal surface of the membrane with the glycosyl phosphatidylinositol (GPI) anchor and excreted in urine at a rate of 50-100 mg per day. THP, uropontin and nephrocalcin are the three known urinary glycoproteins that affect the formation of calcium-containing kidney stones. THP is synthesized by kidney epithelial cells and is believed to play important and diverse roles in the urinary system,including renal water balance, immunosuppression, urinary stone formation and inhibition of bacterial adhesion. THP is nontoxic and blocks early events required for normal T cell proliferation in vitro.