TNFAIP8L2 polyclonal antibody

TNFα-IP 8L2 (tumor necrosis factor, α-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNFα-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNFα-IP 8L2 functions as a negative regulator of T cell receptor function and is thought to promote FAS-induced apoptosis. The gene encoding TNFα-IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.