U2SURP polyclonal antibody

Pre-mRNA splicing enhancer elements are short RNA sequences capable of activating weak splice sites in nearby introns that are required for accurate splice site recognition and control of alternative splicing. Splicing enhancer elements contain specific binding sites for serine/arginine (SR)-rich splicing factors, which include SC35, 9G8, SRp20 and SF2/ASF. The family of SR factors all contain one or more RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain. They are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. SR140, also known as U2-associated SR140 protein or 140 kDa Ser/Arg-rich domain protein, is a 1,029 amino acid member of the splicing factor SR family and consists of a CID domain, a RRM (RNA recognition motif) domain and a SURP motif repeat. SR140 is expressed as three alternatively spliced isoforms and is encoded by a gene located on human chromosome 3.