EXOSC2 polyclonal antibody

The exosome is a multisubunit complex of 3’ to 5’ exoribonucleases. It is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements in their untranslated 3‘ region. EXOSC2 (exosome component 2), also known as p7, RRP4 (ribosomal RNAprocessing protein 4), hRrp4p or Rrp4p, is a component of the exosome multienzyme ribonuclease complex. It contains one S1 RNA-binding domain and localizes to the cytoplasm and nucleolus. In humans, EXOSC2 is phosphorylated within the S1 RNA-binding domain at serine residue 124. This phosphorylation site is conserved from yeast to human, implying that it is of great importance in the cell. EXOSC2 is one of the four exosome subunits known to have exoribonuclease activity. It is required for the processing of the 7S pre-RNA.