PMPCA polyclonal antibody

PMPCA (peptidase (mitochondrial processing) alpha), also known as alpha-MPP, P-55, INPP5E or MPPA, is a 525 amino acid protein that belongs to the peptidase M16 family and exists as a heterodimer of alpha and beta subunits. Localizing to mitochondrial matrix, PMPCA cleaves transit peptides from mitochondrial protein precursors. PMPCA is encoded by a gene that maps to human chromosome 9 , which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.