TRIP12 polyclonal antibody

TRIP12 (thyroid hormone receptor interactor 12) is a 1,992 amino acid E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway. TRIP12 also modulates the NEDD8 pathway, a series of steps implicated in signal transduction and cell cycle progression, where it influences APPBP1 degradation by catalyzing its ubiquitination. A member of the UPL family and K-HECT subfamily, TRIP 12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site. Subject to post-translational phosphorylation upon DNA damage, TRIP12 expression is highest in testis and skeletal muscle, and has also been found in heart, spleen, thymus, ovary, placenta, kidney, prostate and peripheral blood leukocytes at lower levels.