GIPR polyclonal antibody

GIPR (gastric inhibitory polypeptide receptor) is a 466 amino acid protein belonging to the G-protein coupled receptor 2 family. The activity of GIPR is mediated by G proteins, which activate adenylyl cyclase. Expressed as two isoforms produced by alternative splicing, GIPR is a multi-pass cell membrane protein that acts as a receptor for the glucose-dependent insulinotropic polypeptide (GIP). GIP is a major physiologic factor in the augmentation of the insulin response to oral glucose. GIP is a peptide hormone that is released postprandially from the small intestine and acts in concert with glucagon-like peptide (GLP)-1 to potentiate glucose-induced insulin secretion from the pancreatic beta-cell.