GABARAPL1 polyclonal antibody

GABARAPL1 (γ-aminobutyric acid receptor-associated protein-like 1), also known as ATG8, GEC1 (glandular epithelial cell protein 1), APG8L, ATG8L or APG8-LIKE, is a 117 amino acid protein belonging to the MAP1 LC3 family. Localized to the endoplasmic reticulum and Golgi apparatus, GABARAPL1 is ubiquitously expressed. Very high levels of GABARAPL1 are found in brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. GABARAPL1 increases cell-surface expression of κ-type opioid receptor (KOR) through facilitating anterograde intracellular trafficking of the receptor. GABARAPL1 may have chaperone-like effects for many cell surface proteins along the biosynthesis pathway and may regulate the trafficking of receptor GABA. GABARAPL1 interacts with GABAA Rγ2, β Tubulin and KOR-1.