KIR3DL3 polyclonal antibody

KIR3DL3, the most centromeric gene in the KIR gene cluster, maps to chromosome 19. The 410 amino acid KIR3DL3 (also designated KIRC1, KIR3DL7, KIR44 and CD158Z) protein has three Ig domains, an N-terminal signal sequence, a transmembrane region lacking a positively charged residue, and a long cytoplasmic tail containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), but lacks the stalk region found in other KIRs. KIR3DL3 exhibits low or undetectable levels of expression in peripheral blood NK cells. However, demethylation treatment readily induces KIR3DL3 expression in NK cells, indicating that low KIR3DL3 expression in peripheral blood is due to sustained DNA methylation of a functional promoter.