RGS13 polyclonal antibody

RGS13 (regulator of G protein signaling 13) localizes in membrane and nuclear fractions, and is expressed predominantly in tonsil, thymus, lymph node, lung and spleen tissues. Within the lymphoid compartment, highest levels of RGS13 have been found in resting CD19-positive (B cells). Unlike most RGS proteins, RGS13 has no recognizable domain other than the RGS box, but because of its pre-valence in the immune system and lung and its ability to inhibit Gaq, Gai and cAMP generation, the function of RGS13 might be to modulate specific G protein-dependent signal transduction pathways in these regions.