Kinectin 1 polyclonal antibody

Kinectin 1 (KTN1) is an endoplasmic reticulum (ER)-enriched integral membrane protein that may be involved in the formation of ER sheets (reviewed in 1). Kinectin 1 binds the microtubule motor protein kinesin and acts as a membrane anchor for kinesin-based organelle trafficking. The interaction of kinesin with kinectin 1 has been shown to affect ER-supported focal adhesion assembly. Kinectin 1 has also been implicated in translation elongation, as an anchor for the elongation factor complex to the ER. Research investigators have shown that kinectin 1 expression is altered in multiple human pathologies, including breast cancer, hepatocellular carcinoma (HCC), Parkinson's disease , and the autoimmune syndrome Behçet's disease (BD)