Desmoplakin polyclonal antibody

Desmosomes are a class of intracellular junction that tightly link adjacent cells in mechanically stressed tissues such as the epithelium and myocardium . They derive their characteristic strength from the protein Desmoplakin, which acts as a tether by binding the cytoplasmic component of the Desmosome at it’s N-terminus while its C-terminus is anchored to the intermediate-filament cytoskeleton . This association mitigates the impact of mechanical forces on the desmosome by distributing them throughout the cytoskeleton and tissue . Desmoplakin is essential for normal desmosomal adhesion ; defects can result in pathologies that include cardiomyopathy , keratoderma , or the skin blistering disease Epidermolysis bullosa .
Phospho-Desmoplakin (Ser165/166) Antibody is directed against a site that was identified at Cell Signaling Technology (CST) using PTMScan®, our LC-MS/MS platform for modification site discovery. Please visit PhosphoSitePlus®, a modification site knowledgebase developed and maintained by CST, at www.phosphosite.org for more information.