RHCG polyclonal antibody

RhCG (Rhesus blood group family type C glycoprotein), also known as RHGK (Rh glycoprotein kidney), PDRC2 (tumor-related protein DRC2) or SLC42A3, is a multi-pass membrane protein with three potential N-glycosylation sites that belongs to the Rh subfamily of the ammonium transporter family. Expressed in a wide variety of tissues with predominant expression in adult and fetal kidney, RhCG localizes to the apical and/or basolateral cell membrane (depending on the species) and is believed to function as a non-erythroid, bidirectional, electroneutral ammonium transporter. Specifically, RhCG is found throughout the kidney in sites such as the CNT (connecting segment), the DCT (distal convoluted tubule), the collecting duct and the ICT (initial collecting tubule), that are major contributors to renal ammonia secretion. This suggests that RhCG plays an important role in renal ammonia metabolism.